hlaR: Tools for HLA Data

A streamlined tool for eplet analysis of donor and recipient HLA (human leukocyte antigen) mismatch. Messy, low-resolution HLA typing data is cleaned, and imputed to high-resolution using the NMDP (National Marrow Donor Program) haplotype reference database <https://haplostats.org/haplostats>. High resolution data is analyzed for overall or single antigen eplet mismatch using a reference table (currently supporting 'HLAMatchMaker' <http://www.epitopes.net> versions 2 and 3). Data can enter or exit the workflow at different points depending on the user's aims and initial data quality.

Version: 1.0.0
Depends: R (≥ 4.1.0)
Imports: devtools, tidyverse, dplyr, reshape2, schoolmath, tibble, tidyselect, stringr, purrr, tidyr, utils, readr, janitor
Suggests: knitr, rmarkdown
Published: 2023-01-31
DOI: 10.32614/CRAN.package.hlaR
Author: Joan Zhang [aut, cre], Aileen Johnson [aut], Christian P Larsen [cph, aut]
Maintainer: Joan Zhang <joan.zhang at emory.edu>
BugReports: https://github.com/LarsenLab/hlaR/issues
License: MIT + file LICENSE
URL: https://pubmed.ncbi.nlm.nih.gov/35101308/, https://emory-larsenlab.shinyapps.io/hlar_shiny/
NeedsCompilation: no
CRAN checks: hlaR results


Reference manual: hlaR.pdf
Vignettes: Imputation
Eplet Mismatch


Package source: hlaR_1.0.0.tar.gz
Windows binaries: r-devel: hlaR_1.0.0.zip, r-release: hlaR_1.0.0.zip, r-oldrel: hlaR_1.0.0.zip
macOS binaries: r-release (arm64): hlaR_1.0.0.tgz, r-oldrel (arm64): hlaR_1.0.0.tgz, r-release (x86_64): hlaR_1.0.0.tgz, r-oldrel (x86_64): hlaR_1.0.0.tgz
Old sources: hlaR archive


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