MultisiteMediation: Causal Mediation Analysis in Multisite Trials

Multisite causal mediation analysis using the methods proposed by Qin and Hong (2017) <doi:10.3102/1076998617694879>, Qin, Hong, Deutsch, and Bein (2019) <doi:10.1111/rssa.12446>, and Qin, Deutsch, and Hong (2021) <doi:10.1002/pam.22268>. It enables causal mediation analysis in multisite trials, in which individuals are assigned to a treatment or a control group at each site. It allows for estimation and hypothesis testing for not only the population average but also the between-site variance of direct and indirect effects transmitted through one single mediator or two concurrent (conditionally independent) mediators. This strategy conveniently relaxes the assumption of no treatment-by-mediator interaction while greatly simplifying the outcome model specification without invoking strong distributional assumptions. This package also provides a function that can further incorporate a sample weight and a nonresponse weight for multisite causal mediation analysis in the presence of complex sample and survey designs and non-random nonresponse, to enhance both the internal validity and external validity. The package also provides a weighting-based balance checking function for assessing the remaining overt bias.

Version: 0.0.4
Depends: lme4, statmod, psych, MASS, ggplot2
Published: 2021-09-05
DOI: 10.32614/CRAN.package.MultisiteMediation
Author: Xu Qin, Guanglei Hong, Jonah Deutsch, and Edward Bein
Maintainer: Xu Qin <xuqin at>
License: GPL-2
NeedsCompilation: no
In views: CausalInference
CRAN checks: MultisiteMediation results


Reference manual: MultisiteMediation.pdf


Package source: MultisiteMediation_0.0.4.tar.gz
Windows binaries: r-devel:, r-release:, r-oldrel:
macOS binaries: r-release (arm64): MultisiteMediation_0.0.4.tgz, r-oldrel (arm64): MultisiteMediation_0.0.4.tgz, r-release (x86_64): MultisiteMediation_0.0.4.tgz, r-oldrel (x86_64): MultisiteMediation_0.0.4.tgz
Old sources: MultisiteMediation archive


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